Dharminder Chauhan Selected Research

Interleukin-6 (Interleukin 6)

10/2006	MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
9/2005	Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
8/2005	FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
8/2005	Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
6/2005	Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
11/2004	Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
11/2004	VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis.
5/2004	Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
5/2004	GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
11/2003	Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.

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Dharminder Chauhan Research Topics

Disease

145	Multiple Myeloma 01/2022 - 02/2002
75	Neoplasms (Cancer) 01/2021 - 03/2002
7	Plasmacytoma 05/2011 - 11/2002
7	Hematologic Neoplasms (Hematological Malignancy) 02/2009 - 10/2003
4	Bone Diseases (Bone Disease) 03/2014 - 01/2007
4	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 11/2011 - 09/2005
3	Waldenstrom Macroglobulinemia (Macroglobulinemia) 12/2016 - 10/2007
2	Glioma (Gliomas) 01/2018 - 09/2016
2	Necrosis 05/2011 - 04/2005
2	Carcinogenesis 10/2009 - 10/2007
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 10/2007 - 07/2006
2	Lymphoma (Lymphomas) 07/2006 - 10/2003
2	Chromosomal Instability (Chromosome Stability) 01/2003 - 07/2002
1	Bites and Stings (Sting) 01/2021
1	Thrombocytopenia (Thrombopenia) 05/2020
1	Neutropenia 05/2020

Drug/Important Bio-Agent (IBA)

49	Bortezomib (Velcade)FDA Link 01/2021 - 05/2002
39	Proteasome InhibitorsIBA 01/2021 - 05/2002
17	Dexamethasone (Maxidex)FDA LinkGeneric 05/2020 - 02/2002
15	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2019 - 10/2002
14	CytokinesIBA 01/2009 - 05/2002
14	Interleukin-6 (Interleukin 6)IBA 10/2006 - 05/2002
12	Pharmaceutical PreparationsIBA 04/2014 - 03/2002
11	Melphalan (Alkeran)FDA LinkGeneric 09/2017 - 07/2002
11	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2011 - 03/2002
10	Biological ProductsIBA 10/2012 - 05/2002
10	Thalidomide (Thalomid)FDA Link 04/2009 - 05/2002
9	NF-kappa B (NF-kB)IBA 07/2009 - 05/2002
8	Lenalidomide (CC 5013)FDA Link 05/2020 - 11/2002
7	marizomibIBA 01/2018 - 11/2005
7	Phosphotransferases (Kinase)IBA 12/2017 - 11/2003
7	Proteins (Proteins, Gene)FDA Link 08/2017 - 05/2003
7	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2007 - 07/2002
6	CaspasesIBA 06/2013 - 11/2003
6	Insulin-Like Growth Factor I (IGF-1)IBA 10/2006 - 08/2002
5	UbiquitinIBA 01/2021 - 01/2008
5	EnzymesIBA 08/2017 - 03/2004
4	melflufenIBA 05/2020 - 06/2013
4	Caspase 3 (Caspase-3)IBA 08/2017 - 09/2005
4	Histone Deacetylases (Histone Deacetylase)IBA 03/2016 - 10/2003
4	DNA (Deoxyribonucleic Acid)IBA 05/2011 - 03/2003
4	Immunomodulating AgentsIBA 04/2009 - 05/2002
4	Protein Kinase CIBA 02/2009 - 05/2004
4	InterleukinsIBA 01/2009 - 05/2004
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2007 - 01/2003
4	Histone Deacetylase InhibitorsIBA 11/2006 - 05/2003
3	Alkylating AgentsIBA 01/2016 - 07/2008
3	ixazomibIBA 03/2014 - 08/2011
3	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2011 - 12/2004
3	Monoclonal AntibodiesIBA 11/2011 - 05/2003
3	Protein Isoforms (Isoforms)IBA 02/2009 - 12/2003
3	enzastaurinIBA 02/2009 - 02/2007
3	p38 Mitogen-Activated Protein KinasesIBA 05/2008 - 01/2003
3	Immunoglobulins (Immunoglobulin)IBA 12/2007 - 04/2005
3	Insulin-Like PeptidesIBA 09/2005 - 07/2002
3	2-MethoxyestradiolIBA 09/2003 - 09/2002
3	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2003 - 07/2002
2	Phosphopyruvate Hydratase (Enolase)IBA 10/2021 - 01/2020
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2020 - 12/2009
2	CD13 Antigens (Alanine Aminopeptidase)IBA 09/2017 - 06/2013
2	Caspase 8 (Caspase-8)IBA 08/2017 - 12/2011
2	Caspase 9IBA 08/2017 - 12/2011
2	Protein Kinases (Protein Kinase)IBA 01/2017 - 05/2006
2	Nicotinamide PhosphoribosyltransferaseIBA 12/2016 - 08/2013
2	NAD (NADH)IBA 03/2016 - 10/2012
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2015 - 10/2002
2	Biomarkers (Surrogate Marker)IBA 04/2014 - 10/2007
2	MLN2238IBA 03/2014 - 08/2011
2	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2013 - 12/2011
2	ProdrugsIBA 06/2013 - 07/2007
2	Cytochromes c (Cytochrome c)IBA 06/2013 - 09/2005
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2012 - 05/2004
2	Immunoglobulin G (IgG)IBA 11/2011 - 12/2005
2	I-kappa B KinaseIBA 05/2009 - 10/2006
2	GlucocorticoidsIBA 12/2007 - 06/2005
2	B-Cell Activating FactorIBA 10/2007 - 07/2006
2	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 10/2007 - 06/2005
2	AZD 6244IBA 10/2007 - 09/2007
2	perifosineIBA 07/2007 - 05/2006
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 12/2006 - 05/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006 - 07/2006
2	Phosphatidylinositols (Phosphatidylinositol)IBA 05/2006 - 03/2002
2	dacetuzumabIBA 12/2005 - 04/2004
2	Caveolin 1IBA 10/2004 - 02/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2004 - 09/2003
2	Tyrosine (L-Tyrosine)FDA Link 05/2004 - 05/2004
2	Vorinostat FDA Link 01/2004 - 05/2003
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 11/2003 - 05/2003
2	Hydroxamic Acids (Hydroxamic Acid)IBA 10/2003 - 05/2003
2	Insulin (Novolin)FDA Link 09/2003 - 08/2002
2	OligonucleotidesIBA 05/2003 - 02/2002
1	nucleotidaseIBA 01/2022
1	CalreticulinIBA 01/2021
1	Interferon Type IIBA 01/2021
1	KynurenineIBA 01/2020
1	Tryptophan (L-Tryptophan)FDA Link 01/2020
1	pomalidomideIBA 01/2018

Therapy/Procedure

43	Therapeutics 05/2020 - 08/2002
3	Drug Therapy (Chemotherapy) 12/2007 - 03/2004
2	Immunotherapy 05/2004 - 08/2003